Caspase 8 anticorps (N-Term)

N° du produit ABIN187520

L’anticorps Souris Monoclonal anti-Caspase 8 a été validé pour EIA. Il convient pour détecter Caspase 8 dans des échantillons de Humain.

Aperçu rapide pour Caspase 8 anticorps (N-Term) (ABIN187520)

Antigène: Caspase 8 (CASP8)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Caspase 8 est non-conjugé

Application: Enzyme Immunoassay (EIA)

Clone: FLICE-3

Détail du produit anti-Caspase 8 anticorps

Épitope: N-Term

Stérilité: 0.2 μm filtered

Immunogène: Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant human caspase-8 protein and mouse myeloma cells.

Isotype: IgG1

Information d'application

Indications d'application: Western Blot The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Mouse monoclonal antibody against human Caspase-8 (cysteine-requiring aspartate protease-8). Available in 100 µl vials at a concentration of 1 mg/ml (100 µg) in PBS with 0.08% sodium azide. Purified by 0.2 µm sterile filtration.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur Caspase 8

Antigène: Caspase 8 (CASP8)

Autre désignation: Caspase-8

Sujet: Caspases are key effectors of programmed cell death. They are synthesized as inactive pro-enzymes which are activated by cleavage at a specific aspartate residue to form two subunits. These subunits are normally linked together by a linker, which may be involved in the regulation of the different caspases. Caspase-8 is a key enzyme in the apoptosis pathway. Caspase-8 contains two N-terminal region death effector domains, which are removed to activate the enzyme along with cleavage in the two subunits. These subunits then form the active protease, which is capable of cleaving caspase-3, -6 and -7. These caspases are then capable of cleaving other cellular substrates such as PARP and DFF, which in turn induce apoptosis.

Pathways: Apoptose, Caspase Cascade in Apoptosis, Signalisation TLR, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades